3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells

Prasopthum, Aruna; Cooper, Mick; Shakesheff, Kevin M; Yang, Jing

Abstract

The effect of topography in 3D printed polymer scaffolds on stem cell differentiation is a significantly under-explored area. Compared to 2D biomaterials on which various well-defined topographies have been incorporated and been shown to direct an arrange of cell behaviours including adhesion, cytoskeleton organisation and differentiation, incorporating topographical features to 3D polymer scaffolds is challenging due to the difficulty of accessing the inside of a porous scaffold. Only roughened strut surface has been introduced to 3D printed porous

Citation

Prasopthum, A., Cooper, M., Shakesheff, K. M., & Yang, J. (2019). 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells. ACS Applied Materials and Interfaces, 11(21), 18896-18906. https://doi.org/10.1021/acsami.9b01472

• Journal Article Type: Article
• Acceptance Date: May 8, 2019
• Online Publication Date: May 8, 2019
• Publication Date: May 29, 2019
• Deposit Date: May 16, 2019
• Publicly Available Date: May 9, 2020
• Journal: ACS Applied Materials & Interfaces
• Electronic ISSN: 1944-8244
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 21
• Pages: 18896-18906
• DOI: https://doi.org/10.1021/acsami.9b01472
• Keywords: 3D printing; scaffolds; micro-/nano-pores; stem cells; differentiation
• Public URL: https://nottingham-repository.worktribe.com/output/2059117
• Publisher URL: https://pubs.acs.org/doi/10.1021/acsami.9b01472
• Additional Information: This document is the unedited Author’s version of a SubmittedWork that was subsequently accepted for publication in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/toc/aamick/11/21
• Contract Date: May 16, 2019